Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The terrestrial evolution of metabolism and life – by the numbers. | Theoretical Biology and Medical Modelling BioMed Central Open Access Review The terrestrial evolution of metabolism and life - by the numbers Address 392 Pismo St. San Luis Obispo CA 93401 USA Email Gregory C O Kelly - gokelly@ Published 27 August 2009 Received 24 June 2009 Theoretical Biology and Medical Modelling 2009 6 17 doi 1742-4682-6-17 Accepted 27 August 2009 This article is available from http content 6 1 17 2009 O Kelly licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Allometric scaling relating body mass to metabolic rate by an exponent of the former Kleiber s Law commonly known as quarter-power scaling QPS is controversial for claims made on its behalf especially that of its universality for all life. As originally formulated Kleiber was based upon the study of heat metabolic rate is quantified in watts or calories per unit time . Techniques and technology for metabolic energy measurement have been refined but the math has not. QPS is susceptible to increasing deviations from theoretical predictions to data suggesting that there is no single universal exponent relevant to all of life. QPS s major proponents continue to fail to make good on hints of the power of the equation for understanding aging. Essentialist-deductivist view If the equation includes a term for efficiency in the exponent thereby ruling out thermogenesis as part of metabolism its heuristic power is greatly amplified and testable deductive inferences are generated. If metabolic rate is measured in watts and metabolic efficiency is a redox-coupling ratio then the equation is essentially about the energy storage capacity of organic molecules. The equation is entirely about the essentials of all
