Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Diet as prophylaxis and treatment for venous thromboembolism? | Cundiff et al. Theoretical Biology and Medical Modelling 2010 7 31 http content 7 1 31 THEORETICAL BIOLOGY AND MEDICAL MODELLING REVIEW Open Access Diet as prophylaxis and treatment for venous thromboembolism David K Cundiff1 Paul S Agutter2 P Colm Malone3 John C Pezzullo4 Correspondence psa@ 2Theoretical Medicine and Biology Group 26 Castle Hill Glossop Derbyshire SK13 7RR UK 2 BioMed Central Abstract Background Both prophylaxis and treatment of venous thromboembolism VTE deep venous thrombosis DVT and pulmonary emboli PE with anticoagulants are associated with significant risks of major and fatal hemorrhage. Anticoagulation treatment ofVTE has been the standard of care in the USA since before 1962 when the . Food and Drug Administration began requiring randomized controlled clinical trials RCTs showing efficacy so efficacy trials were never required for FDA approval. In clinical trials of high VTE risk surgical patients before the 1980s anticoagulant prophylaxis was clearly beneficial fatal pulmonary emboli FPE without anticoagulants FPE with anticoagulants . However observational studies and RCTs of high VTE risk surgical patients from the 1980s until 2010 show that FPE deaths without anticoagulants are about one-fourth the rate that occurs during prophylaxis with anticoagulants FPE without anticoagulants FPE while receiving anticoagulant prophylaxis . Additionally an FPE rate of about 35 28 400 in patients receiving prophylactic anticoagulants can be attributed to rebound hypercoagulation in the two months after stopping anticoagulants. Alternatives to anticoagulant prophylaxis should be explored. Methods and Findings The literature concerning dietary influences on VTE incidence was reviewed. Hypotheses concerning the etiology of VTE were critiqued in relationship to the rationale for dietary versus anticoagulant approaches to prophylaxis and treatment. Epidemiological evidence suggests that a diet with
