Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A novel approach to modelling water transport and drug diffusion through the stratum corneum. | Marquez-Lago et al. Theoretical Biology and Medical Modelling 2010 7 33 http content 7 1 33 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access A novel approach to modelling water transport and drug diffusion through the stratum corneum Tatiana T Marquez-Lago1 2 Diana M Allen3 Jenifer Thewalt4 Correspondence tatiana. marquez@ dallen@ department of Biosystems Science and Engineering ETH Zurich Mattenstrasse 26 4058 Basel Switzerland 3Department of Earth Sciences Simon Fraser University Burnaby BC V5A 1S6 Canada 2 BioMed Central Abstract Background The potential of using skin as an alternative path for systemically administering active drugs has attracted considerable interest since the creation of novel drugs capable of diffusing through the skin would provide a great step towards easily applicable -and more humane- therapeutic solutions. However for drugs to be able to diffuse they necessarily have to cross a permeability barrier the stratum corneum SC the uppermost set of skin layers. The precise mechanism by which drugs penetrate the skin is generally thought to be diffusion of molecules through this set of layers following a tortuous pathway around corneocytes . impermeable dead cells. Results In this work we simulate water transport and drug diffusion using a threedimensional porous media model. Our numerical simulations show that diffusion takes place through the SC regardless of the direction and magnitude of the fluid pressure gradient while the magnitude of the concentrations calculated are consistent with experimental studies. Conclusions Our results support the possibility for designing arbitrary drugs capable of diffusing through the skin the time-delivery of which is solely restricted by their diffusion and solubility properties. Introduction Recently the potential for using skin as an alternative path for administering systemically active drugs has attracted considerable interest 1 . Among some of the .
