Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Using an expiratory resistor, arterial pulse pressure variations predict fluid responsiveness during spontaneous breathing: an experimental porcine study. | Available online http content 13 2 R39 Research Using an expiratory resistor arterial pulse pressure variations predict fluid responsiveness during spontaneous breathing an experimental porcine study Michael K Dahl Simon T Vistisen Jacob Koefoed-Nielsen and Anders Larsson Open Access Anaesthesia and Intensive Care Medicine North Denmark Region Aalborg Hospital - Aarhus University Hospitals Hobrovej 18-22 DK-9000 Aalborg Denmark Corresponding author Michael K Dahl mida@ Received 23 Oct 2008 Revisions requested 14 Jan 2009 Revisions received 11 Feb 2009 Accepted 20 Mar 2009 Published 20 Mar 2009 Critical Care 2009 13 R39 doi cc7760 This article is online at http content 13 2 R39 2009 Dahl et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Fluid responsiveness prediction is difficult in spontaneously breathing patients. Because the swings in intrathoracic pressure are minor during spontaneous breathing dynamic parameters like pulse pressure variation PPV and systolic pressure variation SPV are usually small. We hypothesized that during spontaneous breathing inspiratory and or expiratory resistors could induce high arterial pressure variations at hypovolemia and low variations at normovolemia and hypervolemia. Furthermore we hypothesized that SPV and PPV could predict fluid responsiveness under these conditions. Methods Eight prone anesthetized and spontaneously breathing pigs 20 to 25 kg were subjected to a sequence of 30 hypovolemia normovolemia and 20 and 40 hypervolemia. At each volemic level the pigs breathed in a randomized order either through an inspiratory and or an expiratory threshold resistor cmH2O or only through the tracheal tube without any .
