Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Remifentanil discontinuation and subsequent intensive care unit-acquired infection: a cohort study. | Available online http content 13 2 R60 Research Remifentanil discontinuation and subsequent intensive care unit-acquired infection a cohort study Saad Nseir1 2 Jeremy Hoel1 Guillaume Grailles1 Aude Soury-Lavergne1 Christophe Di Pompeo2 Daniel Mathieu1 and Alain Durocher1 2 Intensive Care Unit Calmette Hospital University Hospital of Lille boulevard du Pr Leclercq 59037 Lille cedex France 2Medical Assessment Laboratory Lille II University 1 place de Verdun 59045 Lille France Corresponding author Saad Nseir s-nseir@ Received 12 Dec 2008 Revisions requested 30 Jan 2009 Revisions received 4 Mar 2009 Accepted 21 Apr 2009 Published 21 Apr 2009 Critical Care 2009 13 R60 doi cc7788 This article is online at http content 13 2 R60 2009 Nseir et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Recent animal studies demonstrated immunosuppressive effects of opioid withdrawal resulting in a higher risk of infection. The aim of this study was to determine the impact of remifentanil discontinuation on intensive care unit ICU -acquired infection. Methods This was a prospective observational cohort study performed in a 30-bed medical and surgical university ICU during a one-year period. All patients hospitalised in the ICU for more than 48 hours were eligible. Sedation was based on a written protocol including remifentanil with or without midazolam. Ramsay score was used to evaluate consciousness. The bedside nurse adjusted sedative infusion to obtain the target Ramsay score. Univariate and multivariate analyses were performed to determine risk factors for ICU-acquired infection. Results Five hundred and eighty-seven consecutive patients were included in the .
