Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Mobilizing patients in the intensive care unit – from pathophysiology to clinical trials. | Available online http content 13 4 216 Review Bench-to-bedside review Mobilizing patients in the intensive care unit - from pathophysiology to clinical trials Alex D Truong1 Eddy Fan1 Roy G Brower1 and Dale M Needham1 2 1 Division of Pulmonary and Critical Care Medicine Johns Hopkins University Baltimore MD USA 2Department of Physical Medicine and Rehabilitation Johns Hopkins University Baltimore MD USA Corresponding author Dale Needham Published 13 July 2009 This article is online at http content 13 4 216 2009 BioMed Central Ltd Critical Care 2009 13 216 doi cc7885 Abstract As the mortality from critical illness has improved in recent years there has been increasing focus on patient outcomes after hospital discharge. Neuromuscular weakness acquired in the intensive care unit ICU is common persistent and often severe. Immobility due to prolonged bed rest in the ICU may play an important role in the development of ICU-acquired weakness. Studies in other patient populations have demonstrated that moderate exercise is beneficial in altering the inflammatory milieu associated with immobility and in improving muscle strength and physical function. Recent studies have demonstrated that early mobility in the ICU is safe and feasible with a potential reduction in short-term physical impairment. However early mobility requires a significant change in ICU practice with reductions in heavy sedation and bed rest. Further research is required to determine whether early mobility in the ICU can improve patients short-term and long-term outcomes. Introduction Bed rest has been prescribed for a wide range of conditions from acute medical illnesses to postoperative convalescence. In intensive care units ICUs bed rest is especially common 1 2 . However a meta-analysis of 39 randomized trials examining the effect of bed rest on 15 different medical conditions and procedures demonstrated that bed rest was not beneficial and may be .
