Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice. | Available online http content 13 3 R98 Research Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice Toonchai Indrambarya John H Boyd Yingjin Wang Melissa McConechy and Keith R Walley Critical Care Research Laboratories Heart Lung Institute University of British Columbia 166 - 1081 Burrard Street Vancouver British Columbia V6Z 1Y6 Canada Corresponding author John H Boyd jboyd@ Received 5 Mar 2009 Revisions requested 31 Mar 2009 Revisions received 2 Jun 2009 Accepted 23 Jun 2009 Published 23 Jun 2009 Critical Care 2009 13 R98 doi cc7930 This article is online at http content 13 3 R98 2009 Indrambarya et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Arginine vasopressin is a vasoactive drug commonly used in distributive shock states including mixed shock with a cardiac component. However the direct effect of arginine vasopressin on the function of the ischemia reperfusion injured heart has not been clearly elucidated. Methods We measured left ventricular ejection fraction using trans-thoracic echocardiography in C57B6 mice both in normal controls and following ischemia reperfusion injury induced by a one hour ligation of the left anterior descending coronary artery. Mice were treated with one of normal saline dobutamine pg kg min or arginine vasopressin Units kg min equivalent to Units min in a 70 kg human delivered by an intraperitoneal micro-osmotic pump. Arterial blood pressure was measured using a micromanometer catheter. In addition mortality was recorded and cardiac tissues processed for RNA and protein. Results Baseline left ventricular .
