Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Epidermal wound healing in severe sepsis and septic shock in humans. | Available online http content 13 3 R100 Research Epidermal wound healing in severe sepsis and septic shock in humans Marjo Koskela1 2 3 Fiia Gaddnas1 2 3 Tero I Ala-Kokko1 2 3 Jouko J Laurila1 2 3 Juha Saarnio1 2 3 Aarne Oikarinen1 2 3 and Vesa Koivukangas1 2 3 Department of Anesthesiology Division of Intensive Care Medicine Oulu University Hospital Kajaanintie 50 BOX 21 90029 OUH Finland department of Surgery Oulu University Hospital Kajaanintie 50 Oulu BOX 21 90029 OUH Finland department of Dermatology Oulu University Hospital Kajaanintie 50 Oulu BOX 21 90029 OUH Finland Contributed equally Corresponding author Vesa Koivukangas Received 4 Dec 2008 Revisions requested 20 Jan 2009 Revisions received 17 Feb 2009 Accepted 24 Jun 2009 Published 24 Jun 2009 Critical Care 2009 13 R100 doi cc7932 This article is online at http content 13 3 R1 00 2009 Koskela et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The effect of sepsis on epidermal wound healing has not been previously studied. It was hypothesised that epidermal wound healing is disturbed in severe sepsis. Methods Blister wounds were induced in 35 patients with severe sepsis and in 15 healthy controls. The healing of the wounds was followed up by measuring transepidermal water loss and blood flow in the wound reflecting the restoration of the epidermal barrier function and inflammation respectively. The first set of suction blisters early wound was made within 48 hours of the first sepsis-induced organ failure and the second set late wound four days after the first wound. In addition measurements were made on the intact skin. Results The average age of the whole study .
