Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms | Theoretical Biology and Medical Modelling BioMed Central Research Open Access A computational model for functional mapping of genes that regulate intra-cellular circadian rhythms Tian Liu1 Xueli Liu1 Yunmei Chen2 and Rongling Wu 1 Address Department of Statistics University of Florida Gainesville FL 32611 USA and 2Department of Mathematics University of Florida Gainesville Fl 32611 USA Email Tian Liu - tianliu@ Xueli Liu - xueli@ Yunmei Chen - yun@ Rongling Wu - rwu@ Corresponding author Published 30 January 2007 Received 8 October 2006 Theoretical Biology and Medical Modelling 2007 4 5 doi 1742-4682-4-5 Accepted 30 January 2007 This article is available from http content 4 1 5 2007 Liu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Genes that control circadian rhythms in organisms have been recognized but have been difficult to detect because circadian behavior comprises periodically dynamic traits and is sensitive to environmental changes. Method We present a statistical model for mapping and characterizing specific genes or quantitative trait loci QTL that affect variations in rhythmic responses. This model integrates a system of differential equations into the framework for functional mapping allowing hypotheses about the interplay between genetic actions and periodic rhythms to be tested. A simulation approach based on sustained circadian oscillations of the clock proteins and their mRNAs has been designed to test the statistical properties of the model. Conclusion The model has significant implications for probing the molecular genetic mechanism of rhythmic oscillations through the detection of the clock QTL throughout .
