Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " A mathematical model for the adenylosuccinate synthetase reaction involved in purine biosynthesis | Theoretical Biology and Medical Modelling BioMed Central Open Access A mathematical model for the adenylosuccinate synthetase reaction involved in purine biosynthesis Evgeniya A Oshchepkova-Nedosekina and Vitalii A Likhoshvai Address Institute of Cytology and Genetics SB RAS Novosibirsk Russia Email Evgeniya A Oshchepkova-Nedosekina - nzhenia@ Vitalii A Likhoshvai - likho@ Corresponding author Published 27 February 2007 Received 25 September 2006 Theoretical Biology and Medical Modelling 2007 4 11 doi 1742-4682-4-11 Accepted 27 February 2007 This article is available from http content 4 1 1 1 2007 Oshchepkova-Nedosekina and Likhoshvai licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Development of the mathematical models that adequately describe biochemical reactions and molecular-genetic mechanisms is one of the most important tasks in modern bioinformatics. Because the enzyme adenylosuccinate synthetase AdSS has long been extensively studied a wealth of kinetic data has been accumulated. Results We describe a mathematical model for the reaction catalyzed by AdSS. The model s parameters were fitted to experimental data obtained from published literature. The advantage of our model is that it includes relationships between the reaction rate the concentrations of three substrates GTP IMP and ASP the effects of five inhibitors GMP GDP AMP ASUC and SUCC and the influence of Mg2 ions. Conclusion Our model describes the reaction catalyzed by AdSS as a fully random process. The model structure implies that each of the inhibitors included in it is only competitive to one of the substrates. The model was tested for adequacy using experimental data published .
