Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Can visco-elastic phase separation, macromolecular crowding and colloidal physics explain nuclear organisation? | Theoretical Biology and Medical Modelling BioMed Central Open Access Can visco-elastic phase separation macromolecular crowding and colloidal physics explain nuclear organisation Francisco J Iborra Address MRC Molecular Haematology Unit Weatherall Institute of Molecular Medicine John Radcliffe Hospital Headington Oxford OX3 9DS UK Email Francisco J Iborra - Corresponding author Published 12 April 2007 Received 27 October 2006 Theoretical Biology and Medical Modelling 2007 4 15 doi 1742-4682-4-15 Accepted 12 April 2007 This article is available from http content 4 1 15 2007 Iborra licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The cell nucleus is highly compartmentalized with well-defined domains it is not well understood how this nuclear order is maintained. Many scientists are fascinated by the different set of structures observed in the nucleus to attribute functions to them. In order to distinguish functional compartments from non-functional aggregates I believe is important to investigate the biophysical nature of nuclear organisation. Results The various nuclear compartments can be divided broadly as chromatin or protein and or RNA based and they have very different dynamic properties. The chromatin compartment displays a slow constrained diffusional motion. On the other hand the protein RNA compartment is very dynamic. Physical systems with dynamical asymmetry go to viscoelastic phase separation. This phase separation phenomenon leads to the formation of a long-lived interaction network of slow components chromatin scattered within domains rich in fast components .
