Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Lens stem cells may reside outside the lens capsule: an hypothesis | Theoretical Biology and Medical Modelling BioMed Central Open Access Lens stem cells may reside outside the lens capsule an hypothesis Susann G Remington 1 and Rita A Meyer2 Address Ophthalmology Research HealthPartners Medical Group and Research Foundation Regions Hospital 640 Jackson Street St. Paul MN 55101 USA and 2Department of Biomedical Sciences Creighton University Criss I Room 217 2500 California Plaza Omaha NE 68178 USA Email Susann G Remington - RitaAMeyer-ritameyer@ Corresponding author Published 8 June 2007 Received 18 December 2006 Theoretical Biology and Medical Modelling 2007 4 22 doi 1742-4682-4-22 Accepted 8 June 2007 This article is available from http content 4 1 22 2007 Remington and Meyer licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ In this paper we consider the ocular lens in the context of contemporary developments in biological ideas. We attempt to reconcile lens biology with stem cell concepts and a dearth of lens tumors. Historically the lens has been viewed as a closed system in which cells at the periphery of the lens epithelium differentiate into fiber cells. Theoretical considerations led us to question whether the intracapsular lens is indeed self-contained. Since stem cells generate tumors and the lens does not naturally develop tumors we reasoned that lens stem cells may not be present within the capsule. We hypothesize that lens stem cells reside outside the lens capsule in the nearby ciliary body. Our ideas challenge the existing lens biology paradigm. We begin our discussion with lens background information
