Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " The relationship between twitch depression and twitch fade during neuromuscular block produced by vecuronium: correlation with the release of acetylcholine | Theoretical Biology and Medical Modelling BioMed Central Open Access The relationship between twitch depression and twitch fade during neuromuscular block produced by vecuronium correlation with the release of acetylcholine Shashi B Bhatt 1 Jack Kohl1 Anton Amann2 and Vladimir Nigrovic1 Address Department of Anesthesiology College of Medicine University of Toledo Toledo OH USA and 2Department of Anesthesiology and Critical Care Medicine Medical University of Innsbruck Innsbruck Austria and Department of Environmental Sciences Federal Institute of Technology Zurich Switzerland Email Shashi B Bhatt - Jack Kohl - Anton Amann - Vladimir Nigrovic - Corresponding author Published 16 July 2007 Received 8 May 2007 Theoretical Biology and Medical Modelling 2007 4 24 doi 1742-4682-4-24 Accepted 16 July 2007 This article is available from http content 4 1 24 2007 Bhatt et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Train-of-four stimulation pattern following the administration of non-depolarizing neuromuscular blocking drugs reveals fade on successive contractions. Fade is caused by the release of fewer acetylcholine molecules by the fourth A4 than by the first stimulus A1 . The current study was conducted to define the relationship between the clinically observed fade and the simulated decline in acetylcholine release A4 A1 that would be necessary to produce it. Methods The T4 T ratios produced by different doses of vecuronium 15-80 pg-kg-1 were plotted as a function of the concomitant T1.
