Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Functional mapping imprinted quantitative trait loci underlying developmental characteristics | Theoretical Biology and Medical Modelling BioMed Central Research Functional mapping imprinted quantitative trait loci underlying developmental characteristics Yuehua Cui Shaoyu Li and Gengxin Li Address Department of Statistics Probability Michigan State University East Lansing MI 48824 USA Email Yuehua Cui - cui@ Shaoyu Li - lishaoyu@ Gengxin Li - ligengxi@ Corresponding author Open Access Published 17 March 2008 Received 18 January 2008 Theoretical Biology and Medical Modelling 2008 5 6 doi 1742-4682-5-6 Accepted 17 March 2008 This article is available from http content 5 1 6 2008 Cui et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Genomic imprinting a phenomenon referring to nonequivalent expression of alleles depending on their parental origins has been widely observed in nature. It has been shown recently that the epigenetic modification of an imprinted gene can be detected through a genetic mapping approach. Such an approach is developed based on traditional quantitative trait loci QTL mapping focusing on single trait analysis. Recent studies have shown that most imprinted genes in mammals play an important role in controlling embryonic growth and post-natal development. For a developmental character such as growth current approach is less efficient in dissecting the dynamic genetic effect of imprinted genes during individual ontology. Results Functional mapping has been emerging as a powerful framework for mapping quantitative trait loci underlying complex traits showing developmental characteristics. To understand the genetic architecture of dynamic imprinted traits we propose a mapping strategy by integrating the functional mapping
