Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting: a theoretical investigation | Theoretical Biology and Medical Modelling BioMed Central Research The hyperbolic effect of density and strength of inter beta-cell coupling on islet bursting a theoretical investigation Aparna Nittala and Xujing Wang Open Access Address Max McGee National Research Center for Juvenile Diabetes Human and Molecular Genetics Center Medical College of Wisconsin and Children s Research Institute of the Children s Hospital of Wisconsin Milwaukee WI 53226 USA Email Aparna Nittala - anittala@ Xujing Wang - xwang@ Corresponding author Published 3 August 2008 Received 15 June 2008 Theoretical Biology and Medical Modelling 2008 5 17 doi 1742-4682-5-17 Accepted 3 August 2008 This article is available from http content 5 l l7 2008 Nittala and Wang licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Insulin the principal regulating hormone of blood glucose is released through the bursting of the pancreatic islets. Increasing evidence indicates the importance of islet morphostructure in its function and the need of a quantitative investigation. Recently we have studied this problem from the perspective of islet bursting of insulin utilizing a new 3D hexagonal closest packing HCP model of islet structure that we have developed. Quantitative non-linear dependence of islet function on its structure was found. In this study we further investigate two key structural measures the number of neighboring cells that each P-cell is coupled to nc and the coupling strength gc. Results P-cell clusters of different sizes with number of P-cells np ranging from l-343 nc from 012 and gc from 0-1000 pS were simulated. Three functional measures of islet bursting characteristics - fraction of bursting .
