Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Chromatid recommensuration after segmental duplication Mark N Jabbour | Theoretical Biology and Medical Modelling BioMed Central Research Chromatid recommensuration after segmental duplication Mark N Jabbour Open Access Address Department of Pathology American University of Beirut Medical Center Beirut Lebanon Email Mark N Jabbour - Published 7 January 2009 Theoretical Biology and Medical Modelling 2009 6 1 doi 1742-4682-6-1 Received 15 July 2008 Accepted 7 January 2009 This article is available from http content 6 1 1 2009 Jabbour licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Midsegment duplication dup of chromatid arms may be symmetric or asymmetric. It can be argued that every dup should yield a discommensured RC with a loss of at least one duplicated unit to the template counterpart and b deletion of all sections of the replicating chromatid arm that are distal to both the gap left by the duplicating process and the segment closest to the centromere. Hypothesis Mechanisms capable of recommensuring the stack of chromatids after topological shifts of duplicated units dups are discussed. The mechanics might fail in few cases which are discussed in terms of statistics and scalability. Conclusion The dynamics of the highly non-linear processes discussed here may be relevant to duplications of smaller epsilon subunits such as telomeric units within malignant genomes. Background Midsegment duplication dup of chromatid arms has been discussed in 1 . Alternative formats of the process yield duplicated units dups that are either direct . stacked congruently in the chromatid or indirect . stacked upside down along the arm of the hosting chromatid. Indirect dups are rarer 2 . Unlike deletions dups occur infrequently within .
