Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method | Theoretical Biology and Medical Modelling BioMed Central Open Access Examination of effects of GSK3P phosphorylation P-catenin phosphorylation and p-catenin degradation on kinetics of Wnt signaling pathway using computational method Ying-Chieh Sun Address Department of Chemistry National Taiwan Normal University 88 TingChow Road Section 4 Taipei 116 Taiwan Email Ying-Chieh Sun - sun@ Published 22 July 2009 Received 22 April 2009 Theoretical Biology and Medical Modelling 2009 6 13 doi 1742-4682-6-13 Accepted 22 July 2009 This article is available from http content 6 1 13 2009 Sun licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent experiments have explored effects of activities of kinases other than the well-studied GSK3P in wnt pathway signaling particularly at the level of P-catenin. It has also been found that the kinase PKA attenuates P-catenin degradation. However the effects of these kinases on the level and degradation of P-catenin and the resulting downstream transcription activity remain to be clarified. Furthermore the effect of GSK3P phosphorylation on the P-catenin level has not been examined computationally. In the present study the effects of phosphorylation of GSK3P and of phosphorylations and degradation of P-catenin on the kinetics of the wnt signaling pathway were examined computationally. Methods The well-known computational Lee-Heinrich kinetic model of the wnt pathway was modified to include these effects. The rate laws of reactions in the modified model were solved numerically to examine these effects on P-catenin level. Results The computations showed that the P-catenin level is almost linearly proportional to the phosphorylation activity of .
