Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Pharmacokinetics of epinephrine in patients with septic shock: modelization and interaction with endogenous neurohormonal status. | Available online http content 13 4 R120 Open Access Research Pharmacokinetics of epinephrine in patients with septic shock modelization and interaction with endogenous neurohormonal status Imad Abboud1 Nicolas Lerolle1 Saik Urien2 Jean-Marc Tadié1 Franọoise Leviel3 Jean- Yves Fagon1 and Christophe Faisy1 1Medical Intensive Care Unit Hôpital Européen Georges Pompidou Assistance Publique-Hôpitaux de Paris Université Paris - Descartes Paris France . 3620 CIC-0109 Cochin-Necker Paris Descartes Unité de Recherche Clinique Tarnier Hospital Assistance Publique-Hôpitaux de Paris Université Paris - Descartes Paris France Department of Physiology Hôpital Européen Georges Pompidou Assistance Publique-Hôpitaux de Paris Université Paris - Descartes Paris France Corresponding author Nicolas Lerolle nilerolle@ Received 20 Mar 2009 Revisions requested 24 Apr 2009 Revisions received 26 Jun 2009 Accepted 21 Jul 2009 Published 21 Jul 2009 Critical Care 2009 13 R120 doi cc7972 This article is online at http content 13 4 R1 20 2009 Abboud et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In septic patients an unpredictable response to epinephrine may be due to pharmacodynamic factors or to nonlinear pharmacokinetics. The purpose of this study was to investigate the pharmacokinetics of epinephrine and its determinants in patients with septic shock. Methods Thirty-eight consecutive adult patients with septic shock were prospectively recruited immediately before epinephrine infusion. A baseline blood sample C0 was taken to assess endogenous epinephrine norepinephrine renin aldosterone and plasma cortisol levels before epinephrine infusion. At a fixed cumulative epinephrine
