Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Translocation of bacterial NOD2 agonist and its link with inflammation. | Available online http content 13 4 R124 Research Translocation of bacterial NOD2 agonist and its link with inflammation Oh Yoen Kim1 Antoine Monsel2 Michèle Bertrand2 Jean-Marc Cavaillon1 Pierre Coriat2 and Minou Adib-Conquy1 1Cytokines Inflammation Unit Institut Pasteur 28 rue Dr. Roux 75015 Paris France 2Department of Anesthesiology and Critical Care Université Pierre et Marie Curie - Paris 6 and Centre Hospitalier Universitaire Pitié-Salpêtrière Assistance-Publique Hôpitaux de Paris Paris France Corresponding author Jean-Marc Cavaillon jmcavail@ Received 28 May 2009 Revisions requested 3 Jul 2009 Revisions received 9 Jul 2009 Accepted 28 Jul 2009 Published 28 Jul 2009 Critical Care 2009 13 R124 doi cc7980 This article is online at http content 13 4 R1 24 2009 Kim et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The gut is often considered as the motor of critical illness through bacterial translocation which amplifies the inflammatory response and alters the immune status. However systemic bacterial translocation was rarely proven and endotoxin measurement only reflects translocation of Gramnegative-derived products. The process could be more frequently identified if peptidoglycan derived from both Gramnegative and Gram-positive bacteria was measured. Methods We developed a new tool to detect circulating peptidoglycan-like structure using a NOD2-transfected cell line. We also measured plasma and cell-associated endotoxin and different plasma markers of inflammation. We studied 21 patients undergoing abdominal aortic surgery AAS and 21 patients undergoing carotid artery surgery CAS were included as negative controls. Patients were sampled .
