Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Severe influenza A (H1N1)v in patients without any known risk factor. | Available online http content 13 6 425 Letter Severe influenza A H1N1 v in patients without any known risk factor Carles Alonso-Tarrés Cristina Cortes-Lletget Sara Pintado and Assumpta Ricart Microbiology-Consorci de Laboratoris Intercomarcal Hospital General de l Hospitalet Avda. Josep Molins 29-41 L Hospitalet de Llobregat Barcelona 08906 Spain Corresponding author Carles Alonso-Tarrés carlesmicro@ Published 19 November 2009 This article is online at http content 13 6 425 2009 BioMed Central Ltd Critical Care 2009 13 425 doi cc8150 See related research by Rello et al. http content 13 5 R148 A proportion of pandemic flu cases requires critical care. Several risk factors are associated with progressive illness. The World Health Organization recommends prompt antiviral treatment when risk factors are present 1 . Nevertheless in Rello and colleagues work 15 out of 32 critical pandemic flu patients did not have any risk factor 2 . In our hospital 25 pandemic flu cases have been diagnosed by RT-PCR thus far. Three of these cases required critical care. Noteworthy those patients had been visited in emergency services 2 to 3 days before. The clinical picture did not prompt the physician to prescribe any antiviral and oseltamivir treatment was delayed 5 days or more. In contrast in the group of patients who did not require critical care 22 patients only three patients had a prior emergency visit Fisher s exact test P and 18 patients received antiviral treatment in the first 48 hours of symptoms Fisher s exact test P . In Rello and colleagues study the median number of days from illness onset to initiation of antiviral treatment was 4 days. Patients with risk factors were probably treated immediately however and patients without any risk factors were probably treated later. Some evidence suggests that early antiviral treatment is associated with a good prognosis 3 . Rello and colleagues may provide the mean .
