Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: β2 adrenergic agonists in acute lung injury? | Available online http content 13 6 1011 Commentary p2 adrenergic agonists in acute lung injury The heart of the matter Jae W Lee Departments of Anesthesiology and the Cardiovascular Research Institute University of California San Francisco 505 Parnassus Ave San Francisco CA 94143 USA Corresponding author Jae-Woo Lee leejw@ Published 7 December 2009 This article is online at http content 13 6 1011 2009 BioMed Central Ltd Critical Care 2009 13 1011 doi cc8171 See related research by Briot et al. http content 13 5 R166 Abstract Despite extensive research into its pathophysiology acute lung injury acute respiratory distress syndrome ALI ARDS remains a devastating syndrome with mortality approaching 40 . Pharmacologic therapies that reduce the severity of lung injury in vivo and in vitro have not yet been translated to effective clinical treatment options and innovative therapies are needed. Recently the use of P2 adrenergic agonists as potential therapy has gained considerable interest due to their ability to increase the resolution of pulmonary edema. However the results of clinical trials of p agonist therapy for ALI ARDS have been conflicting in terms of benefit. In the previous issue of Critical Care Briot and colleagues present evidence that may help clarify the inconsistent results. The authors demonstrate that in oleic acid lung injury in dogs the inotropic effect of p agonists may recruit damaged pulmonary capillaries leading to increased lung endothelial permeability. In their manuscript Briot and colleagues 1 assessed the role of terbutaline a P2 agonist on lung microvascular permeability in an acute lung injury ALI in vivo model to uncover the underlying mechanisms of therapeutic benefit. The authors used a recently developed broncho-alveolar lavage technique 2 to repeatedly measure every 15 minutes the time-course of capillary-alveolar leakage of a macromolecule fluorescein-labeled dextran .
