Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The propofol infusion syndrome: more puzzling evidence on a complex and poorly characterized disorder. | Available online http content 13 6 1012 Commentary The propofol infusion syndrome more puzzling evidence on a complex and poorly characterized disorder Olaf L Cremer Department of Intensive Care University Medical Centre Utrecht Heidelberglaan 100 3584 CX Utrecht The Netherlands Corresponding author Olaf L Cremer Published 7 December 2009 Critical Care 2009 13 1012 doi cc8177 This article is online at http content 13 6 1012 2009 BioMed Central Ltd See related research by Roberts et al. http content 13 5 R169 Abstract The propofol infusion syndrome is a potentially devastating cardiovascular and metabolic derangement that has been described in both pediatric and adult patients sedated with propofol. Despite a large number of case reports that have appeared in the literature since 1992 the precise clinical features and pathophysiology of this disorder remain uncertain. Historically the syndrome has been characterized by the occurrence of lactic acidosis rhabdomyolysis and circulatory collapse after several days of high-dose propofol infusion. The affected patients were typically young and critically ill and the reported mortality was high. More recently a number of atypical cases have been reported with favorable outcomes. These occurred after short-term or lower-dose infusions in noncritically ill patients in whom generally only a subset of the classical syndrome features was observed. It remains unclear whether these reports reflect true propofol infusion syndrome detected at an earlier and more salvageable stage or mere associations with the use of sedative agents in general. Without better information on the true incidence of the propofol infusion syndrome clinical guidelines on the safe use of this drug remain unsupported by good evidence. Since the propofol infusion syndrome PRIS was first described in 1992 clinical awareness and research interest into this disorder has continued to grow. The
