Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies. | Available online http content 13 6 R188 Research Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma genetic association studies Ling Zeng1 Wei Gu1 Kehong Chen1 Dongpo Jiang2 Lianyang Zhang2 Dingyuan Du3 Ping Hu3 Qing Liu1 Suna Huang1 and Jianxin Jiang1 1State Key Laboratory of Trauma Burns and Combined Injury Research Institute of Surgery Daping Hospital Third Military Medical University Changjiang Road Yuzhong District Chongqing 400042 PR China 2Department of Traumatic Surgery Daping Hospital Third Military Medical University Changjiang Road Yuzhong District Chongqing 400042 PR China 3Chongqing Emergency Medical Center Jiankang Road Yuzhong District Chongqing 400042 PR China Contributed equally Corresponding author Jianxin Jiang hellojjx@ Received 6 Aug 2009 Revisions requested 28 Sep 2009 Revisions received 17 Oct 2009 Accepted 26 Nov 2009 Published 26 Nov 2009 Critical Care 2009 13 R188 doi cc8182 This article is online at http content 13 6 R1 88 2009 Zeng et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction An excessive inflammatory response is thought to account for the pathogenesis of sepsis and multiple organ dysfunction syndrome MODS after severe trauma. The interleukin-10 IL-10 is a potent anti-inflammatory cytokine. The objectives of this prospective study were to investigate the distribution of IL-10 promoter polymorphisms in a cohort of 308 Chinese Han patients with major trauma and to identify associations of IL-10 promoter polymorphisms with IL-10 production and incidence of sepsis and MODS. Methods A total of 308 patients with major trauma were included in this study. The genotypes
