Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Fluid-induced coagulopathy: does the type of fluid make a difference? | Marx and Schuerholz Critical Care 2010 14 118 http content 14 1 118 CRITICAL CARE COMMENTARY L__ Fluid-induced coagulopathy does the type of fluid make a difference Gernot Marx and Tobias Schuerholz See related research of Sossdorf etal. http content 13 6 R208 Abstract Crystalloid and colloid solutions are used for resuscitation of the critically ill. One set of options widely used today are different preparations of hydroxyethyl starch HES . However the safety of HES regarding impairment of blood coagulation remains incompletely elucidated a circumstance that limits its clinical use. Understanding mechanisms and potential differences between low-molecular and low-substituted HES and other HES solutions seems clinically relevant. Since recognizing platelets as an important part in coagulation some 125 years ago the scientific community has evaluated platelets as a key player between inflammation and coagulation. Critically ill patients suffer from both inflammation and impaired coagulation. Thus it is essential to learn more about the mutual influence between these two problems during intensive care therapy. In this context Sossdorf and colleagues 1 evaluated the impact of hydroxyethyl starch HES on thromb-elastography and platelet receptors. The authors investigated 10 HES 200 6 HES 130 and saline in an in vitro experiment with blood of healthy volunteers 1 . HESs are considered effective plasma volume expanders in clinical practice 2 . Adverse effects of HES administration on hemostasis have spurred ongoing research into the pathological mechanisms since these effects are continually discussed as a serious limitation to the clinical use of HES 2 . Sossdorf and colleagues 1 could reveal a decreased maximum clot firmness in FIBTEM rotation thromboelastometry ROTEM -based measurement of Correspondence gmarx@ Department of Intensive Care University Hospital Aachen RWTH Aachen University Pauwelsstrasse 30 52074 .
