Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial. | Barbosa et al. Critical Care 2010 14 R5 http content 14 1 R5 c CRITICAL CARE RESEARCH Open Access Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids inflammatory markers and clinical outcomes in septic patients a randomized controlled clinical trial Vera M Barbosa 1 2 Elizabeth A Miles1 Conceigão Calhau3 Estevão Lafuente2 and Philip C Calder 1 Abstract Introduction The effect of parenteral fish oil in septic patients is not widely studied. This study investigated the effects of parenteral fish oil on plasma phospholipid fatty acids inflammatory mediators and clinical outcomes. Methods Twenty-five patients with systemic inflammatory response syndrome or sepsis and predicted to need parenteral nutrition were randomized to receive either a 50 50 mixture of medium-chain fatty acids and soybean oil or a 50 40 10 mixture of medium-chain fatty acids soybean oil and fish oil. Parenteral nutrition was administrated continuously for five days from admission. Cytokines and eicosanoids were measured in plasma and in lipopolysaccharide-stimulated whole blood culture supernatants. Fatty acids were measured in plasma phosphatidylcholine. Results Fish oil increased eicosapentaenoic acid in plasma phosphatidylcholine P . Plasma interleukin IL -6 concentration decreased significantly more and IL-10 significantly less in the fish oil group both P . At Day 6 the ratio PO2 FiO2 was significantly higher in the fish oil group P and there were fewer patients with PO2 FiO2 200 and 300 in the fish oil group P and P respectively . Days of ventilation length of intensive care unit ICU stay and mortality were not different between the two groups. The fish oil group tended to have a shorter length of hospital stay 22 7 vs. 55 16 days P which became significant 28 9 vs. 82 19 days P when only surviving patients were included. Conclusions Inclusion of fish oil in parenteral nutrition provided to septic ICU .
