Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Argon neuroprotection. | Sanders et al. Critical Care 2010 14 117 http content 14 1 117 CRITICAL CARE COMMENTARY L__ Argon neuroprotection Robert D Sanders - 2 Daqing Ma 2 and Mervyn Maze2-3 See related research by Loetscher etal. http content 3 6 R206 Abstract Certain noble gases though inert exhibit remarkable biological properties. Notably xenon and argon provide neuroprotection in animal models of central nervous system injury. In the previous issue of Critical Care Loetscher and colleagues provided further evidence that argon may have therapeutic properties for neuronal toxicity by demonstrating protection against both traumatic and oxygen-glucose deprivation injury of organotypic hippocampal cultures in vitro. Their data are of interest as argon is more abundant and therefore cheaper than xenon the latter of which is currently in clinical trials for perinatal hypoxic-ischemic brain injury TOBYXe NCT00934700 . We eagerly await in vivo data to complement the promising in vitro data hailing argon neuroprotection. Every noble work is at first impossible. Thomas Carlyle The quest for a therapeutic to ameliorate ischemic and traumatic brain injury is certainly a noble ideal but thus far a futile endeavor. In the previous issue of Critical Care Loetscher and colleagues 1 provided further evidence that the inert noble gases may have ameliorative properties in the setting of acute neuronal injury. Stimulated by a shared interest in the neuroprotective properties of another noble gas xenon 2-4 they have shifted their focus to argon a gas that is more abundant and cheaper to obtain. In their current investigation they demonstrate that argon is neuroprotective when applied after an oxygen-glucose deprivation OGD or traumatic injury in organotypic hippocampal slice cultures in vitro. The models the authors employ are robust the cultured Correspondence Department of Leukocyte Biology National Heart and Lung .
