Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Role of CD14 in lung inflammation and infection. | Anas et al. Critical Care 2010 14 209 http content 14 2 209 CRITICAL CARE REVIEW L_ Role of CD14 in lung inflammation and infection Adam Anas Tom van der Poll and Alex F de Vos This article is one of ten reviews selected from the Yearbook of Intensive Care and Emergency Medicine 2010 Springer Verlag and co-published as a series in Critical Care. Other articles in the series can be found online at http ccforum series yearbook. Further information about the Yearbook of Intensive Care and Emergency Medicine is available from http series 2855. Introduction Toll-like receptors TLR on the surface of cells of the respiratory tract play an essential role in sensing the presence of microorganisms in the airways and lungs. These receptors trigger inflammatory responses activate innate immune responses and prime adaptive immune responses to eradicate invading microbes 1 . TLR are members of a family of pattern-recognition receptors which recognize molecular structures of bacteria viruses fungi and protozoa pathogen-associated molecular patterns or PAMPs as well as endogenous structures and proteins released during inflammation damage danger-associated molecular patterns or DAMPs . To date ten different TLR have been identified in humans and twelve in mice. TLR are expressed on all cells of the immune system but also on parenchymal cells of many organs and tissues. The binding of a PAMP to a TLR results in cellular activation and initiates a variety of effector functions including cytokine secretion proliferation co-stimulation or phagocyte maturation. To facilitate microbial recognition and to amplify cellular responses certain TLR require additional proteins such as lipopolysaccharide LPS binding protein LBP CD14 CD36 and high mobility group box-1 protein HMGB-1 . In this chapter the role of CD14 as an accessory receptor for TLR in lung inflammation and infection is discussed. The central role of CD 14 in the recognition of various PAMPs .
