Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Influence of Factor V Leiden on susceptibility to and outcome from critical illness: a genetic association study. | Benfield et al. Critical Care 2010 14 R28 http content 14 2 R28 c CRITICAL CARE RESEARCH Open Access Influence of Factor V Leiden on susceptibility to and outcome from critical illness a genetic association study Thomas Benfield1 2 Karen Ejrn s3 Klaus Juul4 5 Christian Ostergaard6 Jannik Helweg-Larsen7 Nina Weis1 Lea Munthe-Fog8 Gitte Kronborg1 Marianne Ring Andersen1 Anne Tybjsrg--Hansen2 9 10 Borge G Nordestgaard2 4 10 Peter Garred8 Abstract Introduction Disturbance of the pro-coagulatant and anti-coagulant balance is associated with a poor outcome from critical illness. The objective of this study is to determine whether the Factor V Leiden FVL mutation is associated with susceptibility to or death from critical illness. Methods A genetic association study involving four case cohorts comprising two Gram negative sepsis one invasive pneumococcal disease and one intensive care unit cohort with a total of 1 249 patients. Controls were derived from a population-based cohort study N 8 147 . DNA from patients and controls was genotyped for the FVL mutation. Results When all patients were investigated together no significant difference in the frequency of FVL mutation was observed compared with controls odds ratio OR 95 confidence interval CI to . However when stratified among patients admitted to intensive care N 237 susceptibility and the likelihood of long-term death was influenced by the FVL mutation. In adjusted logistic regression analysis FVL carriers had an increased risk of ICU admission compared to non-carriers OR 95 CI to . In adjusted Cox regression analysis FVL carriers were at increased risk of long-term death compared to non-carriers relative risk 95 CI to . FVL carrier status did not predict either susceptibility to or outcome from Gram negative Escherichia coli or Streptococcus pneumoniae sepsis. Conclusions Overall the FVL mutation did not appear to increase the risk of admission due to severe .
