Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-a in critically ill patients: a prospective observational study. | Yousef et al. Critical Care 2010 14 R33 http content 14 2 R33 c CRITICAL CARE RESEARCH Open Access The diagnostic value of serum leptin monitoring and its correlation with tumor necrosis factor-a in critically ill patients a prospective observational study Ayman Abd Al-Maksoud Yousef1 Yasser Mohamed Amr1 Ghada Abdulmomen Suliman2 Abstract Introduction Severe infection and sepsis are common causes of morbidity and mortality. Early diagnosis in critically ill patients is important to reduce these complications. The present study was conducted to determine the role of serum leptin at early diagnosis and differentiation between patients with manifestations of systemic inflammatory response syndrome SIRS and those with sepsis in patients suffering from a broad range of diseases in the intensive care unit ICU and its correlation with other biomarkers such as C-reactive protein CRP interleukin-6 IL-6 and tumor necrosis factor-a TNF-a . Methods One hundred and six adult ICU patients were observed. CRP leptin IL-6 and TNF-a were compared among the following groups sepsis group n 40 SIRS group n 34 and non-SIRS group n 32 . Patients were classified into these groups at the time of blood analysis for these biomarkers. Results Non-significant differences were observed among patients in different groups regarding biomarkers on the day of ICU admission. On the second day of ICU admission significant elevation of leptin IL-6 and TNF-a occurred in the SIRS and sepsis groups. Delayed elevation of CRP started on the fourth day of ICU admission in patients with sepsis. At the end of the first week only CRP level was elevated in septic patients. Conclusions Serum leptin correlates well with serum level of IL-6 and TNF-a. Leptin helps to differentiate SIRS from non-SIRS patients. CRP is a classic marker of sepsis but is of late onset. Introduction Severe infection and sepsis are major reasons for intensive care unit ICU admission and leading causes for mortality in .
