Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Does anesthetic provide similar neuroprotection to therapeutic hypothermia after cardiac arrest? l cortex. | Zhang Critical Care 2010 14 137 http content 14 2 137 CRITICAL CARE COMMENTARY L__ Does anesthetic provide similar neuroprotection to therapeutic hypothermia after cardiac arrest Hong Zhang 1 2 See related research by Meybohm etal. http content 14 1 R21 Abstract In the previous issue of Critical Care Meybohm and colleagues provide evidence to support hypothermia as a kind of therapeutic option for patients suffering cardiac arrest. Although anesthetics had been used to induce hypothermia sevoflurane post-conditioning fails to confer additional anti-inflammatory effects after cardiac arrest. Further research in this area is warranted. Therapeutic hypothermia has been shown to provide neuroprotection against ischemic injury after cardiac arrest in in vitro and in vivo models. In the previous issue of Critical Care Meybohm and colleagues 1 demonstrate that cardiac arrest triggers the release of cerebral inflammatory cytokines in pigs cerebral cortex. Therapeutic hypothermia alters inflammatory response in cardiac arrest and subsequent cardiopulmonary resuscitation. The combination of hypothermia with sevoflurane post-conditioning does not confer additional antiinflammatory effects compared with hypothermia alone. Cardiac arrest remains the leading cause of death in the US and Europe with an out-of-hospital cardiac arrest survival-to-discharge rate of less than 10 . In-hospital cardiac arrest presents a dismal prognosis. According to a large in-hospital registry the survival-to-discharge rate is 18 whereas that of a developing country is 2 3 . Without prompt care the chance for meaningful survival falls dramatically within minutes of arrest onset. When immediate care is available and victims are successfully resuscitated the majority of these initial survivors subsequently suffer crippling neurologic injury or die in the few days following the cardiac arrest event. Thus improving survival and brain function after initial .
