Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Is albumin use SAFE in patients with traumatic brain injury? | Brackney et al. Critical Care 2010 14 307 http content 14 2 307 CRITICAL CARE JOURNAL CLUB CRITIQUE L Is albumin use SAFE in patients with traumatic brain injury Christopher R Brackney 1 Luis A Diaz 2 Eric B Milbrandt 3 Ali Al-Khafaji3 and Joseph M Darby 4 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club edited by Eric B Milbrandt Expanded Abstract Citation Myburgh J Cooper DJ Finfer S Bellomo R Norton R Bishop N Kai LS Vallance S Saline or albumin for fluid resuscitation in patients with traumatic brain injury. N Engl J Med 2007 357 874-884 1 . Background The Saline versus Albumin Fluid Evaluation study suggested that patients with traumatic brain injury resuscitated with albumin had a higher mortality rate than those resuscitated with saline. The SAFE investigators conducted a post hoc follow-up study of patients with traumatic brain injury who were enrolled in the study. Methods Objective The aims of the study were to document baseline characteristics that are known to influence outcomes from traumatic brain injury in the albumin and saline groups and to compare death and functional neurologic outcomes in the two groups 24 months after randomization. Design A post hoc follow-up study of patients with traumatic brain injury who were enrolled in the SAFE study. Setting Intensive care units of 16 academic tertiary hospitals in Australia and New Zealand. Subjects 460 patients 18 years or older with traumatic brain injury . a history of trauma evidence of head trauma on a computed tomographic CT scan and a score of 13 on the Glasgow Coma Scale GCS . Intervention 231 received four percent albumin and 229 received saline. Outcomes The primary outcome measures were the mortality rate and functional neurologic outcome 24 months after randomization. Multivariate logistic-regression was used to adjustment for baseline covariates known to be associated with increased mortality
