Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Tissue saturation measurement - exciting prospects, but standardisation and reference data still needed. | Jones and Terblanche Critical Care 2010 14 169 http content 14 3 169 CRITICAL CARE COMMENTARY L__ Tissue saturation measurement - exciting prospects but standardisation and reference data still needed Nicola Jones1 and Marius Terblanche1-2 See related research by Mozina and Podbregar http content 14 2 R42 Abstract Sepsis and shock result in disturbances in mieroeireulatory perfusion and tissue oxygen utilisation that may not be reflected in global measures of haemodynamics. Near-infrared spectroscopy enables measurement of tissue oxygen saturation StO2 and provides information on local microvascular and mitochondrial function. This measure could be incorporated with existing targets of goal-directed therapy to provide an integrated approach to haemodynamic resuscitation of both the macro- and microcirculation in various shock states. However key methodological factors must be addressed before widespread clinical application. In the previous issue of Critical Care Mozina and Podbregar report that changes in thenar muscle tissue saturation StO2 in response to vascular occlusion can be used to predict discrepancy between central ScvO2 and mixed SvO2 venous oxygen saturation in patients with combined severe left ventricular failure and sepsis 1 . On first read this study is conceptually difficult. Essentially ScvO2 is a surrogate marker of SvO2 and is widely used to assess adequacy of oxygen delivery and to guide the initial resuscitation of septic patients 2 . Trends in ScvO2 may reflect those in SvO2 but alterations in oxygen extraction and redistribution of blood flow away from peripheral and splanchnic circulations in various shock states may cause clinically important differences between these values 3 . In these circumstances ScvO2 may be maintained despite abnormally low Correspondence department of Critical Care Medicine Guy s and St Thomas NHS Foundation Trust-London SE1 7EH- UK Full list of author .
