Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Does proteolysis explain glutamine release from the septic brain? | Dejong and Olde Damink Critical Care 2010 14 152 http content 14 3 152 CRITICAL CARE COMMENTARY L__ Does proteolysis explain glutamine release from the septic brain Cornelius HC Dejong and Steven WM Olde Damink See related research by Berg etal. http content 14 1 R16 Abstract Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids increased unidirectional phenylalanine uptake and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role but the question is whether this is the case and why this would happen. Berg and colleagues report on the net exchange of amino acids and ammonia across the brain in healthy volunteers before and 1 hour after a 4-hour endotoxin infusion 1 . Amino acids and ammonia were measured in arterial and venous plasma and cerebral blood flow was measured. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids BCAA and aromatic amino acids AAA . This plasma BCAA AAA ratio Fischer ratio was in the past also studied in patients with liver failure. In analogy to this situation the decreased BCAA AAA ratio was mainly the result of a decrease in BCAA and to a lesser degree an increase in phenylalanine. This led to increased arterial delivery of phenylalanine to the brain altered its unidirectional uptake in the brain and was accompanied by an impressive net brain glutamine release. The authors speculate that this may be related to increased cerebral protein breakdown and that these changes may adversely affect brain function for example sepsis-associated encephalopathy . Berg and colleagues study is impressive and one that may be impossible to perform outside Scandinavia. The Correspondence Department of Surgery NUTRIM School for Nutrition Toxicology and .
