Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Endotoxemia-induced inflammation and the effect on the human brain. | van den Boogaard et al. Critical Care 2010 14 R81 http content 14 3 R81 RESEARCH Open Access Endotoxemia-induced inflammation and the effect on the human brain Mark van den Boogaard 1 Bart P Ramakers1 Nens van Alfen2 Sieberen P van der Werf3 Wilhelmina F Fick1 Cornelia W Hoedemaekers1 Marcel M Verbeek45 Lisette Schoonhoven6 Johannes G van der Hoeven1 and Peter Pickkers1 Abstract Introduction Effects of systemic inflammation on cerebral function are not clear as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described. Methods Experimental endotoxemia 2 ng kg Escherichia colilipopolysaccharide LPS was induced in 15 subjects whereas 10 served as controls. Cytokines TNF-a IL-6 IL1-RA and IL-10 cortisol brain specific proteins BSP electroencephalography EEG and cognitive function tests CFTs were determined. Results Following LPS infusion circulating pro- and anti-inflammatory cytokines and cortisol increased P . BSP changes stayed within the normal range in which neuron specific enolase NSE and S100-P changed significantly. Except in one subject with a mild encephalopathic episode without cognitive dysfunction endotoxemia induced no clinically relevant EEG changes. Quantitative EEG analysis showed a higher state of alertness detected by changes in the central region and peak frequency in the occipital region. Improved CFTs during endotoxemia was found to be due to a practice effect as CFTs improved to the same extent in the reference group. Cortisol significantly correlated with a higher state of alertness detected on the EEG. Increased IL-10 and the decreased NSE both correlated with improvement of working memory and with psychomotor speed capacity. No other significant correlations between cytokines cortisol EEG CFT and BSP were found. Conclusions Short-term systemic inflammation does not provoke or explain the occurrence of septic encephalopathy but primarily results in an inflammation-mediated .
