Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study). | Cardoso et al. Critical Care 2010 14 R83 http content 14 3 R83 c CRITICAL CARE RESEARCH Open Access Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle results from the Portuguese community-acquired sepsis study SACiUCI study Teresa Cardoso 1 António Henriques Carneiro1 Orquídea Ribeiro2 Armando Teixeira-Pinto2 and Altamiro Costa-Pereira2 Abstract Introduction To evaluate the impact of compliance with a core version of the Surviving Sepsis Campaign 6-hour bundle on 28 days mortality. Methods Cohort multi-centre prospective study on community-acquired sepsis CAS . Results Seventeen intensive care units ICU entered the study. Over a one year period 4 142 patients were enrolled in the study. Of the 897 24 admitted with CAS 778 87 had severe sepsis or septic shock on ICU admission. In the first six hours of hospital admission 1 62 had serum lactate measured 2 69 fluids administered 3 77 specimens collected for microbiology before antibiotic administration 4 48 blood cultures obtained 5 52 antibiotics administered within the first hour of the diagnosis 6 vasopressors were given in 78 7 56 had central venous measurement CVP measurement 8 17 had a central venous oxygen saturation ScvO2 measurement 9 dobutamine was administered in 52 . Compliance with all actions 1 to 6 core bundle was associated with an odds ratio OR of 95 confidence interval CI in severe sepsis and 95 CI in septic shock for 28 days mortality. This corresponded to a number needed to treat of 6 patients to save one life. Conclusions Compliance with this core bundle was associated with a significant reduction in the 28 days mortality. Urgent action should be taken in order to ensure that early sepsis diagnosis is followed by full completion of this core bundle followed by activation of expertise help in severe sepsis. Introduction Despite great advances in our understanding of its pathophysiology sepsis remains a major reason for .
