Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Standardized intensive care unit management in an anhepatic pig model: new standards for analyzing liver support systems. | Thiel et al. Critical Care 2010 14 R138 http content 14 4 R138 c CRITICAL CARE RESEARCH Open Access Standardized intensive care unit management in an anhepatic pig model new standards for analyzing liver support systems 11 2 3 3 1 Christian Thiel Karolin Thiel Alexander Etspueler Thomas Schenk Matthias H Morgalla Alfred Koenigsrainer Martin Schenk1 Abstract Introduction Several anhepatic pig models were developed in the past. Most models suffer from short anhepatic survival times due to insufficient postoperative intensive care unit ICU management. The aim of this study was to analyze anhepatic survival time under standardized intensive care therapy in a pig model. Methods Eight pigs underwent total hepatectomy after Y-graft interposition between the infrahepatic vena cava and the portal vein to the suprahepatic vena cava. An intracranial probe was inserted for intracranial pressure ICP monitoring. Animals received pressure-controlled ventilation under deep narcosis. Vital parameters were continuously recorded. Urinary output blood gas analysis haemoglobin hematocrit serum electrolytes lactate and glucose were monitored hourly and creatinine prothrombin time international normalised ratio and serum albumin were monitored every 8 hours. Sodium chloride solution hydroxyethyl starch 6 fresh frozen plasma and erythrocyte units were used for volume substitution and norepinephrine was used to prevent severe hypotension. Serum electrolytes and acid-base balance were corrected as required. Antibiotic prophylaxis with ceftriaxon was given daily as well as furosemide to maintain diuresis. Results Postoperative survival was 100 after 24 hours with a maximum survival of 73 mean 58 4 hours. Haemodynamic parameters such as heart rate mean arterial pressure and pulse oximetry remained stable during surgical procedures and following anhepatic status due to ICU therapy until escalating at time of death. Deteriorating pulmonary function could be stabilized by .
