Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Clearing up the confusion: The results of two pilot studies of antipsychotics for ICU delirium. | Qassem and Milbrandt Critical Care 2010 14 316 http content 14 4 316 CRITICAL CARE JOURNAL CLUB CRITIQUE L Clearing up the confusion The results of two pilot studies of antipsychotics for ICU delirium. Zaher Qassem1 and Eric B Milbrandt 2 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club edited by Eric B Milbrandt Expanded Abstracts Citation 1 Girard TD Pandharipande PP Carson SS Schmidt GA Wright PE Canonico AE Pun BT Thompson JL Shintani AK Meltzer HY Bernard GR Dittus RS Ely EW Feasibility efficacy and safety of antipsychotics for intensive care unit delirium the MIND randomized placebo-controlled trial. Crit Care Med 2010 38 428-437 1 . Background Given the lack of compelling evidence supporting the use of antipsychotics for delirium in critically ill patients and the potential adverse effects associated with these medications placebo-controlled clinical trials are greatly needed. Methods Objective To demonstrate the feasibility of a placebo-controlled trial of antipsychotics for delirium in the intensive care unit and to test the hypothesis that antipsychotics would improve days alive without delirium or coma. Design Randomized double-blind placebo-controlled trial. Setting Six tertiary care medical centers in the US. Subjects One hundred one mechanically ventilated medical and surgical intensive care unit patients. Intervention Patients were randomly assigned to receive haloperidol or ziprasidone or placebo every 6 hrs for up to 14 days. Twice each day frequency of study drug administration was adjusted according to delirium status level of sedation and side effects. Outcomes The primary end point was the number of days patients were alive without delirium or coma. Secondary efficacy end points included daily delirium Correspondence emilbrandt@ 2Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh .
