Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: APCAP - activated protein C in acute pancreatitis: a double-blind randomized human pilot trial. | Pettilă et al. Critical Care 2010 14 R139 http content 14 4 R139 c CRITICAL CARE RESEARCH Open Access APCAP - activated protein C in acute pancreatitis a double-blind randomized human pilot trial illo Da-f-f-iI2 1 2I 02 k l22123 M2KÍ2-I 0012 2 k l21212 2 23 Ạ ri I 012122 12ỈO122 i3 l l 11212 2 T211 2 KO121 Ai2i 1 i l l 2 rL L m 124 Ville reilild Led Kyildld IVIdljd LccHd Kyldnpdd All Leppdl nei I li Minnd IdliyieH Allttl Mdrkkold Pauli Puoldkkdinen3 Heikki Repo5 6 Esko Kemppdinen3 Abstract Introduction Previous humdn studies hdve shown low dctivity of protein C APC in severe dcute pdncredtitis SAP . This together with the findings in dnimdl models suggests thdt dctivdted protein C APC mdy protect dgdinst pdncredtic injury dnd dmeliordte the disedse. We therefore evdludted its effect on multiple orgdn dysfunction MOD medsured by the SOFA Sequentidl Orgdn Fdilure Assessment dnd on orgdn-fdilure-free ddys dnd the sdfety of APC in SAP. Methods A prospective double blind randomized pilot study wds use. The study occurred in one university hospitdl tertidry intensive cdre unit ICU with eight beds. The pdtients were chosen dccording to the following inclusion criterid 1 Those ddmitted to the hospitdl 96 h from the onset of pdin 2 Those who hdd d three-fold incredse in serum dmyldse over normdl upper range or dnd in whom computed tomography CT verificdtion of SAP wds noted 3 Those who hdd one or more orgdn dysfunction OD dnd 4 Those in whom less thdn 48 hours hdd pdssed since their first OD. Of d totdl of 215 ddult pdtients with SAP screened between June 2003 dnd August 2007 158 fulfilled the study inclusion criterid. After exclusions 32 pdtients were randomized to the study. The intervention consisted of APC N 16 ddministered intravenously for 96 hours with d dose of 24 gg kg hour or pldcebo N 16 with d simildr infusion rdte. The sdmple size for the study wds cdlculdted dccording to the primdry end-point the chdnge in SOFA during study drug infusion Ddys 0 dnd
