Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Who benefits most from mild therapeutic hypothermia in coronary intervention era? A retrospective and propensity-matched study. | Kagawa et al. Critical Care 2010 14 R155 http content 14 4 R155 c CRITICAL CARE RESEARCH Open Access Who benefits most from mild therapeutic hypothermia in coronary intervention era A retrospective and propensity-matched study Eisuke Kagawa Ichiro Inoue Takuji Kawagoe Masaharu Ishihara Yuji Shimatani Satoshi Kurisu Yasuharu Nakama Kazuoki Dai Takayuki Otani Hiroki Ikenaga Yoshimasa Morimoto Kentaro Ejiri Nozomu Oda Abstract Introduction The aim of the present study was to investigate the impact of the time interval from collapse to return of spontaneous circulation CPA-ROSC in cardiac arrest patients and the types of patients who will benefit from therapeutic hypothermia. Methods Four hundred witnessed adult comatose survivors of out-of-hospital cardiac arrest of cardiac etiology were enrolled in the study. The favorable neurological outcome was defined as category 1 or 2 on the five-point Pittsburgh cerebral performance scale at the time of hospital discharge. A matching process based on the propensity score was performed to equalize potential prognostic factors in the hypothermia and normothermia groups and to formulate a balanced 1 1 matched cohort study. Results The rate of favorable neurological outcome was higher P in the hypothermia group n 110 than in the normothermia group in patients with CPA-ROSC of 15 to 20 minutes 64 vs. 17 20 to 25 minutes 70 vs. 8 25 to 30 minutes 50 vs. 7 35 to 40 minutes 27 vs. 0 and 40 to 45 minutes 29 vs. 2 . A similar association was observed in a propensity-matched cohort but the differences were not significant. There was no significant difference in the rate of favorable neurological outcome between the hypothermia-matched group and the normothermia-matched group. In the patients whose CPA-ROSC was greater than 15 minutes however the rate of favorable neurological outcome was higher in the hypothermia-matched group than in the normothermia-matched group 27 vs. 4 P . In multivariate analysis the CPA-ROSC
