Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial. | Dixon et al. Critical Care 2010 14 R180 http content 14 5 R180 c CRITICAL CARE RESEARCH Open Access Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients a randomized controlled trial 1 2 1 3 1 Barry Dixon Marcus J Schultz Roger Smith James B Fink John D Santamaria Duncan J Campbell Abstract Introduction Prolonged mechanical ventilation has the potential to aggravate or initiate pulmonary inflammation and cause lung damage through fibrin deposition. Heparin may reduce pulmonary inflammation and fibrin deposition. We therefore assessed whether nebulized heparin improved lung function in patients expected to require prolonged mechanical ventilation. Methods Fifty patients expected to require mechanical ventilation for more than 48 hours were enrolled in a double-blind randomized placebo-controlled trial of nebulized heparin 25 000 U or placebo normal saline 4 or 6 hourly depending on patient height. The study drug was continued while the patient remained ventilated to a maximum of 14 days from randomization. Results Nebulized heparin was not associated with a significant improvement in the primary end-point the average daily partial pressure of oxygen to inspired fraction of oxygen ratio while mechanically ventilated but was associated with improvement in the secondary end-point ventilator-free days amongst survivors at day 28 versus treatment difference days 95 CI to P . Heparin administration was not associated with any increase in adverse events. Conclusions Nebulized heparin was associated with fewer days of mechanical ventilation in critically ill patients expected to require prolonged mechanical ventilation. Further trials are required to confirm these findings. Trial registration The Australian Clinical Trials Registry ACTR-12608000121369 . Introduction Each year in the US around 500 000 patients require mechanical ventilation for more than 48 hours 1 . These .
