Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Acidemia does not affect outcomes of patients with acute cardiogenic pulmonary edema treated with continuous positive airway pressure. | Aliberti et al. Critical Care 2010 14 R196 http content 14 6 R196 c CRITICAL CARE RESEARCH Open Access Acidemia does not affect outcomes of patients with acute cardiogenic pulmonary edema treated with continuous positive airway pressure 1 1 2 3 2 Stefano Aliberti Federico Piffer Anna Maria Brambilla Angelo A Bignamini Valentina D Rosti Tommaso Maraffi2 Valter Monzani2 Roberto Cosentini2 Abstract Introduction A lack of data exists in the literature evaluating acidemia on admission as a favorable or negative prognostic factor in patients with acute cardiogenic pulmonary edema ACPE treated with non-invasive continuous positive airway pressure CPAP . The objective of the present study was to investigate the impact of acidemia on admission on outcomes of ACPE patients treated with CPAP. Methods This was a retrospective observational study of consecutive patients admitted with a diagnosis of ACPE to the Emergency Department of IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico Milan Italy between January 2003 and December 2006 treated with CPAP on admission. Two groups of patients were identified subjects with acidemia acidotic group and those with a normal pH on admission controls . The primary endpoint was clinical failure defined as switch to bi-level ventilation switch to endotracheal intubation or inhospital mortality. Results Among the 378 patients enrolled 290 77 were acidotic on admission. A total of 28 patients in the acidotic group and eight patients among controls experienced a clinical failure odds ratio 95 confidence interval to P . Survival analysis indicates that among acidotic patients the time at which 50 of patients reached the threshold was 173 minutes 95 confidence interval 153 to 193 . Neither acidemia P nor the type of acidosis on admission respiratory acidosis P metabolic acidosis P mixed acidosis P affected clinical failure after adjustment for clinical and laboratory .
