Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Possible Cis-acting signal that could be involved in the localization of different mRNAs in neuronal axons | BioMed Central Theoretical Biology and Medical Modelling Research Open Access Possible Cis-acting signal that could be involved in the localization of different mRNAs in neuronal axons Gonzalo E Aranda-Abreu Ma Elena Hernandez Abraham Soto and Jorge Manzo Address Instituto de Neuroetología Universidad Veracruzana Av. Dos Vistas S N km Carr. Xalapa-Veracruz. Col. Industrial-Animas. . 91190. Xalapa Ver. México Email Gonzalo E Aranda-Abreu - garanda@ Ma Elena Hernández - elenahernandez@ Abraham Soto - soca62@ Jorge Manzo - jmanzo@ Corresponding author Published 24 August 2005 Received 21 July 2005 Theoretical Biology and Medical Modelling 2005 2 33 doi 1742-4682-2-33 Accepted 24 August 2005 This article is available from http content 2 1 33 2005 Aranda-Abreu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Messenger RNA mRNA comprises three major parts a 5 -UTR UnTranslated Region a coding region and a 3 -UTR. The 3 -UTR contains signal sequences involved in polyadenylation degradation and localization stabilization processes. Some sequences in the 3 -UTR are involved in the localization of mRNAs in . neurons epithelial cells oocytes and early embryos but such localization has been most thoroughly studied in neurons. Neuronal polarity is maintained by the microtubules MTs found along both dendrites and axon and is partially influenced by sub-cellular mRNA localization. A widely studied mRNA is that for Tau protein which is located in the axon hillock and growth cone its localization depends on the well-characterized cis-acting signal U-rich region in the 3 -UTR. Methods We compared the cis-acting signal of Tau with mRNAs in the axonal regions
