Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A mathematical model of the euglycemic hyperinsulinemic clamp | Theoretical Biology and Medical Modelling BioMed Central Research Open Access A mathematical model of the euglycemic hyperinsulinemic clamp Umberto Picchini 1 Andrea De Gaetano1 Simona Panunzi1 Susanne Ditlevsen2 and Geltrude Mingrone3 Address 1CNR-IASI BioMatLab Rome Italy 2Department of Biostatistics University of Copenhagen Denmark and 3Istituto di Medicina Interna e Geriatria Divisione di Malattie del Ricambio Università Cattolica del Sacro Cuore Policlinico Universitario A. Gemelli Rome Italy Email Umberto Picchini - Andrea De Gaetano - Simona Panunzi - Susanne Ditlevsen - sudi@ Geltrude Mingrone - gmingrone@ Corresponding author Published 03 November 2005 Received 05 August 2005 Accepted 03 November 2005 Theoretical Biology and Medical Modelling 2005 2 44 doi 1742-4682-2-44 H This article is available from http content 2 1 44 2005 Picchini et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Euglycemic Hyperinsulinemic Clamp EHC is the most widely used experimental procedure for the determination of insulin sensitivity and in its usual form the patient is followed under insulinization for two hours. In the present study sixteen subjects with BMI between and kg m2 were studied by long-duration five hours EHC. Results From the results of this series and from similar reports in the literature it is clear that in obese subjects glucose uptake rates continue to increase if the clamp procedure is prolonged beyond the customary 2 hours. A mathematical model of the EHC incorporating delays was fitted to the recorded data and the insulin .
