Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Distinguishing between linear and exponential cell growth during the division cycle: Single-cell studies, cell-culture studies, and the object of cell-cycle research | BioMed Central Theoretical Biology and Medical Modelling Commentary Open Access Distinguishing between linear and exponential cell growth during the division cycle Single-cell studies cell-culture studies and the object of cell-cycle research Stephen Cooper Address Department of Microbiology and Immunology University of Michigan Medical School Ann Arbor Michigan 48109-0620 USA Email Stephen Cooper - cooper@ Corresponding author Published 23 February 2006 Received 01 September 2005 Theoretical Biology and Medical Modelling 2006 3 10 doi 1742-4682-3-10 Accepted 23 February 2006 This article is available from http content 3 1 10 2006 Cooper licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Two approaches to understanding growth during the cell cycle are single-cell studies where growth during the cell cycle of a single cell is measured and cell-culture studies where growth during the cell cycle of a large number of cells as an aggregate is analyzed. Mitchison has proposed that single-cell studies because they show variations in cell growth patterns are more suitable for understanding cell growth during the cell cycle and should be preferred over culture studies. Specifically Mitchison argues that one can glean the cellular growth pattern by microscopically observing single cells during the division cycle. In contrast to Mitchison s viewpoint it is argued here that the biological laws underlying cell growth are not to be found in single-cell studies. The cellular growth law can and should be understood by studying cells as an aggregate. Results The purpose or objective of cell cycle analysis is presented and discussed. These ideas are applied to the controversy between .
