Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A statistical method for predicting splice variants between two groups of samples using GeneChip® expression array data | BioMed Central Theoretical Biology and Medical Modelling Research Open Access A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data Wenhong Fan1 Najma Khalid1 Andrew R Hallahan2 3 James M Olson2 and Lue Ping Zhao 1 Address 1Division of Public Health Sciences Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N. Seattle WA 98109 USA 2Clinical Research Division Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N. Seattle WA 98109 USA and 3Department of Paediatrics and Child Health University of Queensland QLD 4029 Australia Email Wenhong Fan - wfan@ Najma Khalid - nkhalid@ Andrew R Hallahan - James M Olson - jolson@ Lue Ping Zhao - lzhao@ Corresponding author Published 07 April 2006 Received 23 January 2006 Theoretical Biology and Medical Modelling 2006 3 19 doi 1742-4682-3-19 Accepted 07 April 2006 This article is available from http content 3 1 19 2006 Fan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Alternative splicing of pre-messenger RNA results in RNA variants with combinations of selected exons. It is one of the essential biological functions and regulatory components in higher eukaryotic cells. Some of these variants are detectable with the Affymetrix GeneChip that uses multiple oligonucleotide probes . probe set since the target sequences for the multiple probes are adjacent within each gene. Hybridization intensity from a probe correlates with abundance of the corresponding transcript. Although the multiple-probe feature in the current GeneChip was designed to assess expression values of individual genes it also measures .
