Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Intravenous lipid emulsion in clinical toxicology | Rothschild et al. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2010 18 51 http content 18 1 51 SCANDINAVIAN JOURNAL OF Et emergency medicine REVIEW Open Access Intravenous lipid emulsion in clinical toxicology Leelach Rothschild1 Sarah Bern1 Sarah Oswald1 Guy Weinberg1 2 Abstract Intravenous lipid emulsion is an established effective treatment for local anesthetic-induced cardiovascular collapse. The predominant theory for its mechanism of action is that by creating an expanded intravascular lipid phase equilibria are established that drive the offending drug from target tissues into the newly formed lipid sink . Based on this hypothesis lipid emulsion has been considered a candidate for generic reversal of toxicity caused by overdose of any lipophilic drug. Recent case reports of successful resuscitation suggest the efficacy of lipid emulsion infusion for treating non-local anesthetic overdoses across a wide spectrum of drugs beta blockers calcium channel blockers parasiticides herbicides and several varieties of psychotropic agents. Lipid emulsion therapy is gaining acceptance in emergency rooms and other critical care settings as a possible treatment for lipophilic drug toxicity. While protocols exist for administration of lipid emulsion in the setting of local anesthetic toxicity no optimal regimen has been established for treatment of acute non-local anesthetic poisonings. Future studies will shape the evolving recommendations for lipid emulsion in the setting of non-local anesthetic drug overdose. Introduction Intravenous lipid emulsion ILE is a novel method for treating local anesthetic systemic toxicity LAST that also shows promise as an effective antidote for other lipophilic drug poisonings. Cardiovascular collapse is the most life-endangering complication of local anesthetic LA absorption or intravascular injection during regional anesthesia 1 . LAST is generally considered to be resistant to conventional modes of .
