Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical aspects of a nationwide epidemic of severe haemolytic uremic syndrome (HUS) in children | Krogvold et al. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine 2011 19 44 http content 19 1 44 I SCANDINAVIAN JOURNAL OF Et emergency medicine ORIGINAL RESEARCH Open Access Clinical aspects of a nationwide epidemic of severe haemolytic uremic syndrome HUS in children I nrr I I 1 Th fs I_IS-. V I r n r S-. 1 A D V s Z-I V VL s F 3 I_l A fs I I S-. v-4 I_l slnn Cl 1 1 Wil I -J r n V5 Lars Krogvold inore Henrichsen Anna Bjerre Damien Brackman Henrik DOiiner Helga Gudmundsdottir Gaute Syversen6 Pal AKsel N ss7 and Hans Jacob BangstaQ1 Abstract Background Report a nationwide epidemic of Shiga toxin-producing E. coli STEC O103 H25 causing hemolytic uremic syndrome D HUS in children. Methods Description of clinical presentation complications and outcome in a nationwide outbreak. Results Ten children median age years developed HUS during the outbreak. One of these was presumed to be a part of the outbreaK without microbiological proof. Eight of the patients were oligoanuric and in need of dialysis. Median need for dialysis was 15 days one girl did not regain renal function and received a Kidney transplant. Four patients had seizures and or reduced consciousness. Cerebral oedema and herniation caused the death of a 4-year-old boy. Two patients developed necrosis of colon with perforation and one of them developed non-autoimmune diabetes. Conclusion This outbreak of STEC was characterized by a high incidence of HUS among the infected children and many developed severe renal disease and extrarenal complications. A likely explanation is that the O103 H25 eae and stx2-positive strain was highly pathogen and we suggest that this serotype should be looked for in patients with HUS caused by STEC especially in severe forms or outbreaks. Background Haemolytic uremic syndrome HUS is a severe acute and dramatic disease affecting previously healthy children. HUS is defined as a triad of acute kidney injury microangiopatic haemolytic anaemia and .
