Textbook of Interventional Cardiovascular Pharmacology phần 5

Quy định đại thực bào và tế bào cơ trơn của thành mạch máu. Gây cytokine tiết PDGF tế bào nội mô. Gây ra sự gia tăng của các tế bào cơ trơn của mạch máu RANTES tường. Chemokine bắt giữ có hiệu quả nhất. Ảnh hưởng đến các đại thực bào bám dính | 20 Iron chelation deferoxamine and beyond Valeri S. Chekanov Introduction Investigations have shown that iron may contribute to endothelial cell function and increase the risk of cardiovascular disease. It is believed that strong metal chelators such as deferoxamine DFO can counteract iron cation formation. The primary targets of iron chelators used for treating iron overload are prevention of iron ingress into tissues and its intracellular scavenging. Iron Body iron stores An average adult human absorbs and excretes in iron balance 1 mg of iron each day. Even slight disturbances in this balance may lead to general or local iron overload or iron deficiency. Iron is essential for all cells for heme synthesis and obtained from extracellular transferrin. Mitochondrial and extramitochondrial cytochromes oxygen-storage proteins and hemoglobin and myoglobin are needed in heme iron. The liver is adapted to store and release iron when needed. Normally all cells regulate the suitable level of catalytically active iron pool during iron uptake synthesis of iron-containing proteins and iron release. Excess iron can interact with oxygen to form very toxic superoxide and hydroxyl radicals. Several points are important to cardiovascular pharmacology in the case of iron overload damage of endothelium as a base for development of atherosclerosis and tissue ischemia existence in the iron pool of a weakly bound low-molecular-weight iron complex and the possibility of the iron chelating drugs DFO interacting with this chelatable iron. Iron and endothelial function Nonprotein-bound iron may directly inactivate endothelium-derived nitric oxide 1 depress endothelial dysfunction and be a potential mechanism for iron-related cardiovascular disease 2 . Because the endothelium participates in the release of several paracrine factors including nitric oxide it is critical in regulating vasomotor tone platelet activity leukocyte adhesion vascular smooth muscle proliferation and endothelial .