Thay đổi sinh học thần kinh xảy ra xung quanh thời điểm khởi đầu của rối loạn tâm thần toàn diện cũng có thể được ngăn chặn, giảm thiểu, hoặc đảo ngược. Do đó, giai đoạn báo trước trình bày hai mục tiêu có thể can thiệp | 37. Treatment of the Schizophrenia Prodrome 381 ing the onset of diagnosable psychotic disorder arises. Neurobiological changes that occur around the time of onset of full-blown psychotic disorder might also be prevented minimized or reversed. Thus the prodromal phase presents two possible targets for intervention 1 current symptoms behavior or disability and 2 prevention of further decline into frank psychotic disorder. Aside from these two treatment aims there are a number of other benefits of treatment of people during the prodrome. Individuals experiencing this early phase of the disorder may engage more quickly with treatment than those who present late when psychotic symptoms are entrenched social networks are more disrupted and functioning has further deteriorated. Additionally the individual may be more likely to accept treatment if full-blown psychosis does emerge compared to the individual who has been unwell for a longer time before seeking assistance. This may be especially so given that the person is likely already to have developed a therapeutic relationship with a treating team. Effective treatment can be provided rapidly if the person does develop psychosis possibly avoiding the need for hospitalization and minimizing the deleterious effect of extended untreated psychosis. Finally prepsychotic intervention offers the chance to research the onset phase of psychotic illness which may provide insight into the core features of the psychopathology and psychobiology of psychosis. However intervention during the prodromal phase is an approach that carries risks as well as benefits. The most salient of these is the issue of false positives which are individuals who are identified as being at risk of developing a psychotic disorder but who in fact are not destined to develop a psychotic disorder. These individuals may be harmed by being labeled as being at high risk of psychosis and may receive treatment unnecessarily. Clearly it is difficult to distinguish
