Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Validation of a new transpulmonary thermodilution system to assess global enddiastolic volume and extravascular lung water. | Bendjelid et al. Critical Care 2010 14 R209 http content 14 6 R209 c CRITICAL CARE RESEARCH Open Access Validation of a new transpulmonary thermodilution system to assess global end-diastolic volume and extravascular lung water Karim Bendjelid1 Raphael Giraud1 Nils Siegenthaler1 Frederic Michard2 Abstract Introduction A new system has been developed to assess global end-diastolic volume GEDV a volumetric marker of cardiac preload and extravascular lung water EVLW from a transpulmonary thermodilution curve. Our goal was to compare this new system with the system currently in clinical use. Methods Eleven anesthetized and mechanically ventilated pigs were instrumented with a central venous catheter and a right PulsioCath Pulsion Munich Germany and a left VolumeView Edwards Lifesciences Irvine CA USA thermistor-tipped femoral arterial catheter. The right femoral catheter was used to measure GEDV and EVLW using the PiCCO2 Pulsion method GEDV1 and EVLW1 respectively . The left femoral catheter was used to measure the same parameters using the new VolumeView Edwards Lifesciences method GEDV2 and EVLW2 respectively . Measurements were made during inotropic stimulation dobutamine during hypovolemia bleeding during hypervolemia fluid overload and after inducing acute lung injury intravenous oleic acid . Results One hundred and thirty-seven paired measurements were analyzed. GEDV1 and GEDV2 ranged from 701 to 1 629 ml and from 774 to 1 645 ml respectively. GEDV1 and GEDV2 were closely correlated r2 with mean bias of -11 80 ml and percentage error of 14 . EVLW1 and EVLW2 ranged from 507 to 2 379 ml and from 495 to 2 222 ml respectively. EVLW1 and EVLW2 were closely correlated r2 with mean bias of -5 72 ml and percentage error of 15 . Conclusions In animals and over a very wide range of values a good agreement was found between the new VolumeView system and the PiCCO system to assess GEDV and EVLW. Introduction Transpulmonary thermodilution TPTD is .